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| 카탈로그 번호 | HT072014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PPM1D Polyclonal Antibody (HT072014) is a rabbit polyclonal antibody detecting PPM1D in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PPM1D (Ser96-Leu395). | ||||||||
| 타겟 | Protein phosphatase 1D, 3.1.3.16, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O15297 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein phosphatase 1D (PPM1D) is a ~66 kDa protein. Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. 1. Ruark, E. et al. (2013) Nature 493, 406-10. PMID: 23242139 2. Lu, X. et al. (2005) Genes & development 19, 1162-74. PMID: 15870257 3. Fujimoto, H. et al. (2006) Cell death and differentiation 13, 1170-80. PMID: 16311512 4. An, H. et al. (2011) PloS one 6, e16427. PMID: 21283629 | ||||||||
| 참고사항 | For research use only. |
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