Anti-Human PPP5C Polyclonal Antibody (HW456014)

Name: Anti-Human PPP5C Polyclonal Antibody
Brand: abinScience
SKU: HW456014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HW456014

설명

Anti-Human PPP5C Polyclonal Antibody (HW456014) is a rabbit polyclonal antibody detecting PPP5C in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PPP5C (Asp22-Met499).

타겟

PP-T, Protein phosphatase T, Serine/threonine-protein phosphatase 5, PPP5, PPT, PP5, PPP5C

정제

Purified by antigen affinity column.

등록번호

P53041

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine/threonine-protein phosphatase 5 (PPP5C) is a ~56 kDa protein. Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function.

1. Wechsler, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 1247-52. PMID: 14734805

2. Ikeda, K. et al. (2004) Molecular endocrinology (Baltimore, Md.) 18, 1131-43. PMID: 14764652

3. Ali, A. et al. (2004) Genes & development 18, 249-54. PMID: 14871926

4. Zeke, T. et al. (2005) The Biochemical journal 385, 45-56. PMID: 15383005

5. Liu, F. et al. (2005) The Journal of biological chemistry 280, 1790-6. PMID: 15546861

6. Zhang, J. et al. (2005) Molecular and cellular biology 25, 9910-9. PMID: 16260606

7. Partch, CL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 10467-10472. PMID: 16790549

8. von Kriegsheim, A. et al. (2006) Nature cell biology 8, 1011-6. PMID: 16892053

9. Kang, Y. et al. (2009) The Journal of biological chemistry 284, 9845-53. PMID: 19176521

10. Chatterjee, A. et al. (2010) The Journal of biological chemistry 285, 3872-3882. PMID: 19948726

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human PPP5C Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PPP5C Polyclonal Antibody (HW456014)

개요

이미지

참고 문헌

데이터시트

SDS