Anti-Human PRMT6 Polyclonal Antibody (HP638014)

Name: Anti-Human PRMT6 Polyclonal Antibody
Brand: abinScience
SKU: HP638014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP638014

설명

Anti-Human PRMT6 Polyclonal Antibody (HP638014) is a rabbit polyclonal antibody detecting PRMT6 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PRMT6 (Arg82-Asp375).

타겟

Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, Protein arginine N-methyltransferase 6, PRMT6, HRMT1L6

정제

Purified by antigen affinity column.

등록번호

Q96LA8

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Protein arginine N-methyltransferase 6 (PRMT6) is a ~41 kDa protein. Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53.

1. Guccione, E. et al. (2007) Nature 449, 933-7. PMID: 17898714

2. Iberg, AN. et al. (2008) The Journal of biological chemistry 283, 3006-3010. PMID: 18077460

3. Hyllus, D. et al. (2007) Genes & development 21, 3369-80. PMID: 18079182

4. Lakowski, TM. et al. (2009) The Biochemical journal 421, 253-61. PMID: 19405910

5. Yan, WW. et al. (2018) EMBO reports 19. PMID: 30420520

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human PRMT6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PRMT6 Polyclonal Antibody (HP638014)

개요

이미지

참고 문헌

데이터시트

SDS