中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HW641013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1782 | ||||
| 타겟 | PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P49768 | ||||
| RRID | Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. 1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644 2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183 3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990 4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883 5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933 6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784 7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439 8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632 9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383 10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
