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| 카탈로그 번호 | HX952014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PSME3 Polyclonal Antibody (HX952014) is a rabbit polyclonal antibody detecting PSME3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PSME3 (Ser111-Tyr254). | ||||||||
| 타겟 | Activator of multicatalytic protease subunit 3, Proteasome activator complex subunit 3, PA28g, 11S regulator complex subunit gamma, PA28gamma, Ki nuclear autoantigen, REG-gamma, PSME3, Proteasome activator 28 subunit gamma | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P61289 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Proteasome activator complex subunit 3 (PSME3) is a ~29 kDa protein. Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition. 1. Magni, M. et al. (2014) Nucleic acids research 42, 13150-60. PMID: 25361978 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-PSME3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Hela cell lysate
Lane 3: K562 cell lysate
Lane 4: 293T cell lysate
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