中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HF630014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PTTG1 Polyclonal Antibody (HF630014) is a rabbit polyclonal antibody detecting PTTG1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PTTG1 (Asn121-Asp190). | ||||||||
| 타겟 | PTTG1, Esp1-associated protein, EAP1, Securin, TUTR1, PTTG, hPTTG, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95997 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Securin (PTTG1) is a ~22 kDa protein. Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-PTTG1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Daudi cell lysate
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
