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| 카탈로그 번호 | HP968014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RAB23 (Met1-Ser186). | ||||||||
| 타겟 | RAB23, Ras-related protein Rab-23 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9ULC3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ras-related protein Rab-23 (RAB23) is a ~26 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In conjunction with IFT57 and KIF17, it drives the localization of specific G protein-coupled receptors, such as the dopamime receptor DRD1, to primary cilia. Has a critical role in the formation and elongation of neuronal primary cilia, thereby impacting the activation of sonic hedgehog (Shh) signaling. Additionally, it is involved in the down-regulation of Shh signaling by cooperating with SUFU to prevent the nuclear import of GLI1 transcription factor, thus suppressing its transcriptional activity. 1. Leaf, A. et al. (2015) eLife 4. PMID: 26182404 2. Leong, WY. et al. (2025) PLoS genetics 21, e1011611. PMID: 40825043 3. Chi, S. et al. (2012) Cellular signalling 24, 1222-8. PMID: 22365972 4. Chau, YY. et al. (2025) The Journal of biological chemistry 301, 108036. PMID: 39615683 5. Nozawa, T. et al. (2012) Cellular microbiology 14, 1149-65. PMID: 22452336 | ||||||||
| 참고사항 | For research use only. |
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