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| 카탈로그 번호 | HP954014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RAB39B (Met1-Gly192). | ||||||||
| 타겟 | RAB39B, Ras-related protein Rab-39B | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96DA2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ras-related protein Rab-39B (RAB39B) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39B is involved in autophagy and may function in autophagosome formation. Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission. May regulate the homeostasis of SNCA/alpha-synuclein. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 | ||||||||
| 참고사항 | For research use only. |
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