

| 카탈로그 번호 | HB696014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human RAB6A Polyclonal Antibody (HB696014) is a rabbit polyclonal antibody detecting RAB6A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RAB6A (Arg12-Gly176). | ||||||||
| 타겟 | Ras-related protein Rab-6A, Rab-6, RAB6A, RAB6 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P20340 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ras-related protein Rab-6A (RAB6A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. 1. Matsuto, M. et al. (2015) Biochimica et biophysica acta 1853, 2592-609. PMID: 25962623 2. Seifert, W. et al. (2015) The Journal of biological chemistry 290, 3349-58. PMID: 25492866 | ||||||||
| 참고사항 | For research use only. |
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