Anti-Human RAB8A Polyclonal Antibody (HX163014)

Name: Anti-Human RAB8A Polyclonal Antibody
Brand: abinScience
SKU: HX163014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HX163014

설명

Anti-Human RAB8A Polyclonal Antibody (HX163014) is a rabbit polyclonal antibody detecting RAB8A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RAB8A (Lys21-Ser181).

타겟

RAB8, MEL, Ras-related protein Rab-8A, Oncogene c-mel, RAB8A

정제

Purified by antigen affinity column.

등록번호

P61006

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ras-related protein Rab-8A (RAB8A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi.

1. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297

2. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634

3. Roland, JT. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2789-94. PMID: 21282656

4. Chen, Y. et al. (2012) Cell research 22, 333-45. PMID: 21844891

5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148

6. Murga-Zamalloa, CA. et al. (2010) Human molecular genetics 19, 3591-8. PMID: 20631154

7. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

8. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433

9. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human RAB8A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RAB8A Polyclonal Antibody (HX163014)

개요

이미지

참고 문헌

데이터시트

SDS