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| 카탈로그 번호 | HX977014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human RACK1 Polyclonal Antibody (HX977014) is a rabbit polyclonal antibody detecting RACK1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RACK1 (Met1-Arg317). | ||||||||
| 타겟 | RACK1, Human lung cancer oncogene 7 protein, Guanine nucleotide-binding protein subunit beta-like protein 12.3, GNB2L1, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-2-like 1, Receptor of activated protein C kinase 1, Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed, Receptor for activated C kinase, Small ribosomal subunit protein RACK1, HLC-7 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P63244 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Small ribosomal subunit protein RACK1 is a ~35 kDa protein. Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. 1. Anger, AM. et al. (2013) Nature 497, 80-5. PMID: 23636399 2. Sundaramoorthy, E. et al. (2017) Molecular cell 65, 751-760.e4. PMID: 28132843 3. Ikebuchi, Y. et al. (2009) Hepatology research : the official journal of the Japan Society of Hepatology 39, 1091-107. PMID: 19674157 4. Cao, XX. et al. (2011) Breast cancer research and treatment 126, 555-63. PMID: 20499158 | ||||||||
| 참고사항 | For research use only. |
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