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| 카탈로그 번호 | HP636014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RBM15B (Asn710-Ala890). | ||||||||
| 타겟 | HuOTT3, RBM15B, One-twenty two protein 3, OTT3, RNA-binding motif protein 15B, HsOTT3, Putative RNA-binding protein 15B | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8NDT2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Putative RNA-binding protein 15B (RBM15B) is a ~97 kDa protein. RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. 1. Hiriart, E. et al. (2005) The Journal of biological chemistry 280, 36935-45. PMID: 16129689 2. Patil, DP. et al. (2016) Nature 537, 369-373. PMID: 27602518 3. Loyer, P. et al. (2011) The Journal of biological chemistry 286, 147-59. PMID: 21044963 4. Uranishi, H. et al. (2009) The Journal of biological chemistry 284, 26106-16. PMID: 19586903 | ||||||||
| 참고사항 | For research use only. |
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