Anti-Human RICTOR Polyclonal Antibody (HP601014)

Name: Anti-Human RICTOR Polyclonal Antibody
Brand: abinScience
SKU: HP601014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

50ug
100ug

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HP601014

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RICTOR (Arg32-Glu140).

타겟

KIAA1999, Rapamycin-insensitive companion of mTOR, hAVO3, RICTOR, AVO3 homolog

정제

Purified by antigen affinity column.

등록번호

Q6R327

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Rapamycin-insensitive companion of mTOR (RICTOR) is a ~192 kDa protein. Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2.

1. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

2. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

3. Dibble, CC. et al. (2009) Molecular and cellular biology 29, 5657-70. PMID: 19720745

4. Julien, LA. et al. (2010) Molecular and cellular biology 30, 908-21. PMID: 19995915

5. Chen, CH. et al. (2011) Science signaling 4, ra10. PMID: 21343617

6. Scaiola, A. et al. (2020) Science advances 6. PMID: 33158864

7. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

8. Yu, Z. et al. (2022) The Journal of biological chemistry 298, 102288. PMID: 35926713

9. Treins, C. et al. (2010) Oncogene 29, 1003-16. PMID: 19935711

10. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human RICTOR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RICTOR Polyclonal Antibody (HP601014)

개요

이미지

참고 문헌

데이터시트

SDS

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