Anti-Human RNF186 Polyclonal Antibody (HA313014)

Name: Anti-Human RNF186 Polyclonal Antibody
Brand: abinScience
SKU: HA313014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HA313014

설명

Anti-Human RNF186 Polyclonal Antibody (HA313014) is a rabbit polyclonal antibody detecting RNF186 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RNF186 (Gly32-Val150).

타겟

RNF186, RING finger protein 186, E3 ubiquitin-protein ligase RNF186

정제

Purified by antigen affinity column.

등록번호

Q9NXI6

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase RNF186 is a ~24 kDa protein. E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3.

1. Wang, P. et al. (2013) Cellular signalling 25, 2320-33. PMID: 23896122

2. Ranjan, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34623328

3. Zhang, H. et al. (2021) Autophagy 17, 3030-3047. PMID: 33280498

4. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human RNF186 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RNF186 Polyclonal Antibody (HA313014)

개요

이미지

참고 문헌

데이터시트

SDS

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