Anti-Human RNF2 Polyclonal Antibody (HA051014)

Name: Anti-Human RNF2 Polyclonal Antibody
Brand: abinScience
SKU: HA051014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HA051014

설명

Anti-Human RNF2 Polyclonal Antibody (HA051014) is a rabbit polyclonal antibody detecting RNF2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RNF2 (Glu225-Lys336).

타겟

Huntingtin-interacting protein 2-interacting protein 3, RING-type E3 ubiquitin transferase RING2, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, DING, RING finger protein 1B, BAP1, Protein DinG, RING1B, RING finger protein 2, HIPI3, RNF2, RING finger protein BAP-1, RING1b

정제

Purified by antigen affinity column.

등록번호

Q99496

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase RING2 (RNF2) is a ~37 kDa protein. E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.

1. Wang, H. et al. (2004) Nature 431, 873-8. PMID: 15386022

2. Cao, R. et al. (2005) Molecular cell 20, 845-54. PMID: 16359901

3. Bentley, ML. et al. (2011) The EMBO journal 30, 3285-97. PMID: 21772249

4. McGinty, RK. et al. (2014) Nature 514, 591-6. PMID: 25355358

5. Gao, Z. et al. (2014) Nature 516, 349-54. PMID: 25519132

6. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332

7. Luo, X. et al. (2021) Human molecular genetics 30, 1283-1292. PMID: 33864376

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human RNF2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RNF2 Polyclonal Antibody (HA051014)

개요

이미지

참고 문헌

데이터시트

SDS