Anti-Human RPS6KA5 Polyclonal Antibody (HF754014)

Name: Anti-Human RPS6KA5 Polyclonal Antibody
Brand: abinScience
SKU: HF754014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HF754014

설명

Anti-Human RPS6KA5 Polyclonal Antibody (HF754014) is a rabbit polyclonal antibody detecting RPS6KA5 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RPS6KA5 (Met1-Phe348).

타겟

RPS6KA5, RSK-like protein kinase, MSK1, Ribosomal protein S6 kinase alpha-5, Nuclear mitogen- and stress-activated protein kinase 1, 90 kDa ribosomal protein S6 kinase 5, RSKL, S6K-alpha-5

정제

Purified by antigen affinity column.

등록번호

O75582

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ribosomal protein S6 kinase alpha-5 (RPS6KA5) is a ~89 kDa protein. Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.

1. Wiggin, GR. et al. (2002) Molecular and cellular biology 22, 2871-81. PMID: 11909979

2. Janknecht, R. (2003) Oncogene 22, 746-55. PMID: 12569367

3. Wierenga, AT. et al. (2003) Experimental hematology 31, 398-405. PMID: 12763138

4. Beck, IM. et al. (2008) The EMBO journal 27, 1682-93. PMID: 18511904

5. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510

6. New, L. et al. (1999) The Journal of biological chemistry 274, 1026-32. PMID: 9873047

7. Vermeulen, L. et al. (2003) The EMBO journal 22, 1313-24. PMID: 12628924

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human RPS6KA5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RPS6KA5 Polyclonal Antibody (HF754014)

개요

이미지

참고 문헌

데이터시트

SDS