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| 카탈로그 번호 | HB727013 |
|---|---|
| 브랜드 | abinScience |
| 종 반응성 | Monkey, Macaca mulatta (Rhesus macaque) |
| 응용 분야 | FuncS, IHC, Neut, Inhib |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | 5C3 |
| 타겟 | Protein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100A4, CAPL, MTS1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P26447, P07091 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Protein S100-A4 (S100A4) is a ~11 kDa protein. Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. 1. Li, ZH. et al. (2006) Cancer research 66, 5173-80. PMID: 16707441 2. Orre, LM. et al. (2013) Oncogene 32, 5531-40. PMID: 23752197 3. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770 4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597 |
| 참고사항 | For research use only |
SDS-PAGE for Anti-Human S100A4 Antibody (5C3)
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