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| 카탈로그 번호 | HA923014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human SAR1B Polyclonal Antibody (HA923014) is a rabbit polyclonal antibody detecting SAR1B in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SAR1B (Met1-Asp198). | ||||||||
| 타겟 | GTP-binding protein SAR1b, SAR1B, SARB, GTP-binding protein B, SARA2, GTBPB | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9Y6B6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Small COPII coat GTPase SAR1B is a ~22 kDa protein. Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis. In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. 1. Cutrona, MB. et al. (2013) Traffic (Copenhagen, Denmark) 14, 691-708. PMID: 23433038 2. Melville, DB. et al. (2020) The Journal of biological chemistry 295, 8401-8412. PMID: 32358066 3. Wang, X. et al. (2021) Cell metabolism 33, 350-366.e7. PMID: 33186557 4. Huang, Q. et al. (2023) Proteins 91, 518-531. PMID: 36369712 5. Chen, J. et al. (2021) Nature 596, 281-284. PMID: 34290409 | ||||||||
| 참고사항 | For research use only. |
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