中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HC664014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human SCN5A Polyclonal Antibody (HC664014) is a rabbit polyclonal antibody detecting SCN5A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
|
||||||||
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SCN5A (Ser1787-Gln1931). | ||||||||
| 타겟 | Sodium channel protein type V subunit alpha, SCN5A, Sodium channel protein type 5 subunit alpha, hH1, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q14524 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Sodium channel protein type 5 subunit alpha (SCN5A) is a ~226 kDa protein. Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat. 1. Gellens, ME. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 554-8. PMID: 1309946 2. Kattygnarath, D. et al. (2011) Circulation. Cardiovascular genetics 4, 261-8. PMID: 21447824 3. Núñez, L. et al. (2013) Heart rhythm 10, 264-72. PMID: 23085483 4. Chakrabarti, S. et al. (2013) Circulation. Arrhythmia and electrophysiology 6, 392-401. PMID: 23420830 5. Gabelli, SB. et al. (2014) Nature communications 5, 5126. PMID: 25370050 6. Wang, L. et al. (2015) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36, 2250-62. PMID: 26279430 7. Musa, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 12528-33. PMID: 26392562 8. Kinoshita, K. et al. (2016) Heart rhythm 13, 1113-1120. PMID: 26776555 9. Tan, HL. et al. (2001) Nature 409, 1043-7. PMID: 11234013 10. Wang, DW. et al. (2002) Circulation 105, 341-6. PMID: 11804990 | ||||||||
| 참고사항 | For research use only. |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
