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| 카탈로그 번호 | HA065013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1911 | ||||
| 타겟 | Signal peptide, CUB and EGF-like domain-containing protein 2, SCUBE2, Protein CEGP1, Scube/You, CEGP1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9NQ36 | ||||
| RRID | Anti-Human SCUBE2 Antibody (SAA1911) (abinScience Cat# HA065013, RRID:AB_3727675) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) is a ~109 kDa protein. Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. 1. Creanga, A. et al. (2012) Genes & development 26, 1312-25. PMID: 22677548 2. Tukachinsky, H. et al. (2012) Cell reports 2, 308-20. PMID: 22902404 3. Jakobs, P. et al. (2014) Journal of cell science 127, 1726-37. PMID: 24522195 4. Lin, YC. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 144-155. PMID: 27834687 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SCUBE2 Antibody (SAA1911)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
