Anti-Human SETD1A Polyclonal Antibody (HC879014)

Name: Anti-Human SETD1A Polyclonal Antibody
Brand: abinScience
SKU: HC879014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HC879014

설명

Anti-Human SETD1A Polyclonal Antibody (HC879014) is a rabbit polyclonal antibody detecting SETD1A. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SETD1A (Val1524-Ser1670).

타겟

EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase complex subunit SET1, hSET1A

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15047

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation.

1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868

2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738

3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342

4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650

5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159

6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human SETD1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SETD1A Polyclonal Antibody (HC879014)

개요

이미지

참고 문헌

데이터시트

SDS