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| 카탈로그 번호 | HP870013 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human SETD7 IP Recombinant Antibody (SAA0223) (HP870013) is a mouse monoclonal antibody detecting SETD7 in ELISA, IF, IP. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA0223 | ||||
| 타겟 | Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7 | ||||
| 내독소 수준 | < 10 EU/mg as determined by LAL method. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q8WTS6 | ||||
| RRID | Anti-Human SETD7 IP Antibody (SAA0223) (abinScience Cat# HP870013, RRID:AB_3729757) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. 1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497 2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 11850410 3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855 4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998 5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209 9. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392 | ||||
| 참고사항 | For research use only. | ||||
| Isotype Control | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507) Mouse IgG2a Recombinant Isotype Control Antibody (S43.10) (MF533307) |
SDS-PAGE for Anti-Human SETD7 IP Antibody (SAA0223).
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