Anti-Human SETD7 Polyclonal Antibody (HP870014)

Name: Anti-Human SETD7 Polyclonal Antibody
Brand: abinScience
SKU: HP870014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

HP870014

설명

Anti-Human SETD7 Polyclonal Antibody (HP870014) is a rabbit polyclonal antibody detecting SETD7 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SETD7 (Met1-Lys366).

타겟

Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7

정제

Purified by antigen affinity column.

등록번호

Q8WTS6

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.

1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497

2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 11850410

3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855

4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998

5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209

9. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SETD7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SETD7 Polyclonal Antibody (HP870014)

개요

이미지

참고 문헌

데이터시트

SDS