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| 카탈로그 번호 | HS762013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | SAA0224 | ||||
| 타겟 | Histone-lysine N-methyltransferase SETMAR, SETMAR, SET domain and mariner transposase fusion protein, Metnase | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q53H47 | ||||
| RRID | Anti-Human SETMAR IP Antibody (SAA0224) (abinScience Cat# HS762013, RRID:AB_3729758) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Histone-lysine N-methyltransferase SETMAR is a ~78 kDa protein. Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining. 1. Lee, SH. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 18075-80. PMID: 16332963 2. Cordaux, R. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 8101-6. PMID: 16672366 3. Miskey, C. et al. (2007) Molecular and cellular biology 27, 4589-600. PMID: 17403897 4. Roman, Y. et al. (2007) Biochemistry 46, 11369-76. PMID: 17877369 5. Beck, BD. et al. (2008) The Journal of biological chemistry 283, 9023-30. PMID: 18263876 6. Goodwin, KD. et al. (2010) Biochemistry 49, 5705-13. PMID: 20521842 7. Hromas, R. et al. (2012) Oncogene 31, 4245-54. PMID: 22231448 8. Kim, HS. et al. (2014) The Journal of biological chemistry 289, 10930-10938. PMID: 24573677 9. Fnu, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 540-5. PMID: 21187428 10. Williamson, EA. et al. (2008) Nucleic acids research 36, 5822-31. PMID: 18790802 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SETMAR IP Antibody (SAA0224)
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