Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

Name: Anti-Human SH3RF1 Polyclonal Antibody
Brand: abinScience
SKU: HD618014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD618014

설명

Anti-Human SH3RF1 Polyclonal Antibody (HD618014) is a rabbit polyclonal antibody detecting SH3RF1. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SH3RF1 (Gln135-Lys268).

타겟

E3 ubiquitin-protein ligase SH3RF1, EC:2.3.2.27, KIAA1494, POSH, POSH1, Plenty of SH3s, Protein POSH, RING finger protein 142, RING-type E3 ubiquitin transferase SH3RF1, RNF142, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2, SH3MD2, SH3RF1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q7Z6J0

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

E3 ubiquitin-protein ligase SH3RF1 is a ~93 kDa protein. Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation.

1. Alroy, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1478-83. PMID: 15659549

2. Kärkkäinen, S. et al. (2010) FEBS letters 584, 3867-72. PMID: 20696164

3. Lin, DH. et al. (2009) The Journal of biological chemistry 284, 29614-24. PMID: 19710010

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human SH3RF1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

개요

이미지

참고 문헌

데이터시트

SDS