Anti-Human SHOC2 Polyclonal Antibody (HP134014)

Name: Anti-Human SHOC2 Polyclonal Antibody
Brand: abinScience
SKU: HP134014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HP134014

설명

Anti-Human SHOC2 Polyclonal Antibody (HP134014) is a rabbit polyclonal antibody detecting SHOC2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SHOC2 (Ser86-Val582).

타겟

Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2

정제

Purified by antigen affinity column.

등록번호

Q9UQ13

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.

1. Li, W. et al. (2000) Genes & development 14, 895-900. PMID: 10783161

2. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891

3. Hannig, V. et al. (2014) Human mutation 35, 1290-4. PMID: 25137548

4. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504

5. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882

6. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509

7. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SHOC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SHOC2 Polyclonal Antibody (HP134014)

개요

이미지

참고 문헌

데이터시트

SDS