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| 카탈로그 번호 | HT426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SIAH2 (Ser68-Pro324). | ||||||||
| 타겟 | RING-type E3 ubiquitin transferase SIAH2, SIAH2, hSiah2, Seven in absentia homolog 2, Siah-2, E3 ubiquitin-protein ligase SIAH2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O43255 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | E3 ubiquitin-protein ligase SIAH2 is a ~34 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. 1. Boehm, J. et al. (2001) The EMBO journal 20, 4153-62. PMID: 11483518 2. Szargel, R. et al. (2009) The Journal of biological chemistry 284, 11706-16. PMID: 19224863 3. Hu, G. et al. (1997) Genes & development 11, 2701-14. PMID: 9334332 | ||||||||
| 참고사항 | For research use only. |
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