Anti-Human SKIV2L Polyclonal Antibody (HS917014)

Name: Anti-Human SKIV2L Polyclonal Antibody
Brand: abinScience
SKU: HS917014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HS917014

설명

Anti-Human SKIV2L Polyclonal Antibody (HS917014) is a rabbit polyclonal antibody detecting SKIV2L in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SKIV2L (Gly803-His975).

타겟

SKIV2L, Helicase SKI2W, W, Helicase-like protein, HLP, SKI2W, Ski2, SKIV2, DDX13

정제

Purified by antigen affinity column.

등록번호

Q15477

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Superkiller complex protein 2 (SKIV2L) is a ~137 kDa protein. Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.

1. Zhu, B. et al. (2005) Genes & development 19, 1668-73. PMID: 16024656

2. Zinoviev, A. et al. (2020) Molecular cell 77, 1340-1349.e6. PMID: 32006463

3. Kögel, A. et al. (2022) Molecular cell 82, 756-769.e8. PMID: 35120588

4. Nicholson-Shaw, T. et al. (2025) RNA (New York, N.Y.) 31, 1195-1205. PMID: 40441874

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SKIV2L Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SKIV2L Polyclonal Antibody (HS917014)

개요

이미지

참고 문헌

데이터시트

SDS