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| 카탈로그 번호 | HX905013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1576 | ||||
| 타겟 | MCT 1, SLC16A1, Monocarboxylate transporter 1, MCT1, Solute carrier family 16 member 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P53985 | ||||
| RRID | Anti-Human SLC16A1/MCT1 Antibody (SAA1576) (abinScience Cat# HX905013, RRID:AB_3727337) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Monocarboxylate transporter 1 (SLC16A1/MCT1) is a ~53 kDa protein. Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. 1. Galić, S. et al. (2003) The Biochemical journal 376, 413-22. PMID: 12946269 2. Reddy, A. et al. (2020) Cell 183, 62-75.e17. PMID: 32946811 3. Wang, N. et al. (2021) Cell 184, 370-383.e13. PMID: 33333023 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SLC16A1/MCT1 Antibody (SAA1576)
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