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| 카탈로그 번호 | HP208014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SLC22A12 (Glu281-Thr350). | ||||||||
| 타겟 | Urate anion exchanger 1, Organic anion transporter 4-like protein, OATL4, Solute carrier family 22 member 12, RST, URAT1, SLC22A12, Renal-specific transporter | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96S37 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Solute carrier family 22 member 12 (SLC22A12) is a ~59 kDa protein. Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. 1. Enomoto, A. et al. (2002) Nature 417, 447-52. PMID: 12024214 2. Tasic, V. et al. (2011) PloS one 6, e28641. PMID: 22194875 3. Shinoda, Y. et al. (2022) Drug metabolism and pharmacokinetics 43, 100443. PMID: 35144162 4. Toyoda, Y. et al. (2022) Frontiers in pharmacology 13, 842717. PMID: 35462902 5. Miura, D. et al. (2011) The journal of physiological sciences : JPS 61, 253-7. PMID: 21350910 | ||||||||
| 참고사항 | For research use only. |
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