Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

Name: Anti-Human SLC22A6 Polyclonal Antibody
Brand: abinScience
SKU: HS924014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HS924014

설명

Anti-Human SLC22A6 Polyclonal Antibody (HS924014) is a rabbit polyclonal antibody detecting SLC22A6 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SLC22A6 (Thr41-Arg131).

타겟

hROAT1, PAH transporter, Solute carrier family 22 member 6, PAHT, Renal organic anion transporter 1, hPAHT, OAT1, SLC22A6, Organic anion transporter 1, hOAT1

정제

Purified by antigen affinity column.

등록번호

Q4U2R8

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.

1. Jung, KY. et al. (2001) Life sciences 69, 2123-35. PMID: 11669456

2. Kimura, H. et al. (2002) The Journal of pharmacology and experimental therapeutics 301, 293-8. PMID: 11907186

3. Deguchi, T. et al. (2004) Kidney international 65, 162-74. PMID: 14675047

4. Uwai, Y. et al. (2012) Pharmacological research 65, 254-60. PMID: 22108572

5. Uwai, Y. et al. (2013) Bioscience, biotechnology, and biochemistry 77, 1517-21. PMID: 23832370

6. Ohashi, A. et al. (2017) Molecular and cellular biochemistry 435, 97-108. PMID: 28534121

7. Lu, R. et al. (1999) The American journal of physiology 276, F295-303. PMID: 9950961

8. Hosoyamada, M. et al. (1999) The American journal of physiology 276, F122-8. PMID: 9887087

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SLC22A6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

개요

이미지

참고 문헌

데이터시트

SDS