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| 카탈로그 번호 | HA125013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-mFc | ||||
| 클론 ID | SAA1974 | ||||
| 타겟 | Electroneutral Na/HCO(3) cotransporter, Sodium bicarbonate cotransporter 3, NBC3, Sodium bicarbonate cotransporter 2, NBCn1, Solute carrier family 4 member 7, Bicarbonate transporter, SLC4A6, NBC2, SBC2, Sodium bicarbonate cotransporter 2b, NBC2B, BT, SLC4A7 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9Y6M7 | ||||
| RRID | Anti-Human SLC4A7 Antibody (SAA1974) (abinScience Cat# HA125013, RRID:AB_3727738) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 30 mM Histidine, pH5.8, 10% sucrose, 0.02% Tween80 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Sodium bicarbonate cotransporter 3 (SLC4A7) is a ~136 kDa protein. Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. 1. Pushkin, A. et al. (1999) The Journal of biological chemistry 274, 16569-75. PMID: 10347222 2. Park, M. et al. (2002) The Journal of biological chemistry 277, 50503-9. PMID: 12403779 3. Loiselle, FB. et al. (2003) Molecular membrane biology 20, 307-17. PMID: 14578046 4. Loiselle, FB. et al. (2004) American journal of physiology. Cell physiology 286, C1423-33. PMID: 14736710 5. Sedlyarov, V. et al. (2018) Cell host & microbe 23, 766-774.e5. PMID: 29779931 6. Ali, ES. et al. (2022) Molecular cell 82, 3284-3298.e7. PMID: 35772404 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SLC4A7 Antibody (SAA1974)
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