Anti-Human SLCO1A2 Polyclonal Antibody (HW453014)

Name: Anti-Human SLCO1A2 Polyclonal Antibody
Brand: abinScience
SKU: HW453014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW453014

설명

Anti-Human SLCO1A2 Polyclonal Antibody (HW453014) is a rabbit polyclonal antibody detecting SLCO1A2. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SLCO1A2 (Phe406-Phe513).

타겟

OATP, OATP-1, OATP-A, OATP1, OATP1A2, Organic anion-transporting polypeptide 1, SLC21A3, SLCO1A2, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, Solute carrier organic anion transporter family member 1A2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P46721

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Solute carrier organic anion transporter family member 1A2 (SLCO1A2) is a ~74 kDa protein. Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids. Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs.

1. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463

2. Kullak-Ublick, GA. et al. (1995) Gastroenterology 109, 1274-82. PMID: 7557095

3. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 11159893

4. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656

5. Zhou, F. et al. (2013) The AAPS journal 15, 1099-108. PMID: 23918469

6. Chan, T. et al. (2015) British journal of pharmacology 172, 2343-53. PMID: 25560245

7. Kullak-Ublick, GA. et al. (1998) FEBS letters 424, 173-6. PMID: 9539145

8. Bailey, DG. et al. (2007) Clinical pharmacology and therapeutics 81, 495-502. PMID: 17301733

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human SLCO1A2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SLCO1A2 Polyclonal Antibody (HW453014)

개요

이미지

참고 문헌

데이터시트

SDS