Anti-Human SMN1 Polyclonal Antibody (HS868014)

Name: Anti-Human SMN1 Polyclonal Antibody
Brand: abinScience
SKU: HS868014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HS868014

설명

Anti-Human SMN1 Polyclonal Antibody (HS868014) is a rabbit polyclonal antibody detecting SMN1. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SMN1 (Met1-Asn294).

타겟

Component of gems 1, Gemin-1, SMN, SMN1, SMNT, Survival motor neuron protein

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q16637

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Survival motor neuron protein (SMN1) is a ~31 kDa protein. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits.

1. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161

2. Pellizzoni, L. et al. (1998) Cell 95, 615-24. PMID: 9845364

3. Otter, S. et al. (2007) The Journal of biological chemistry 282, 5825-33. PMID: 17178713

4. Zhang, R. et al. (2011) Cell 146, 384-95. PMID: 21816274

5. Tripsianes, K. et al. (2011) Nature structural & molecular biology 18, 1414-20. PMID: 22101937

6. Yi, H. et al. (2020) Nucleic acids research 48, 895-911. PMID: 31799625

7. Lotti, F. et al. (2012) Cell 151, 440-54. PMID: 23063131

8. Zhao, DY. et al. (2016) Nature 529, 48-53. PMID: 26700805

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SMN1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SMN1 Polyclonal Antibody (HS868014)

개요

이미지

참고 문헌

데이터시트

SDS