Anti-Human SNX17 Polyclonal Antibody (HC387014)

Name: Anti-Human SNX17 Polyclonal Antibody
Brand: abinScience
SKU: HC387014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HC387014

설명

Anti-Human SNX17 Polyclonal Antibody (HC387014) is a rabbit polyclonal antibody detecting SNX17 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SNX17 (Met1-Gly401).

타겟

KIAA0064, SNX17, Sorting nexin-17

정제

Purified by antigen affinity column.

등록번호

Q15036

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Sorting nexin-17 (SNX17) is a ~52 kDa protein. Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

1. Williams, R. et al. (2004) Molecular biology of the cell 15, 3095-105. PMID: 15121882

2. Knauth, P. et al. (2005) Journal of molecular biology 347, 813-25. PMID: 15769472

3. Singla, A. et al. (2024) Nature communications 15, 10193. PMID: 39587083

4. Ghai, R. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7763-8. PMID: 21512128

5. Steinberg, F. et al. (2012) The Journal of cell biology 197, 219-30. PMID: 22492727

6. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079

7. Czubayko, M. et al. (2006) Biochemical and biophysical research communications 345, 1264-72. PMID: 16712798

8. Donoso, M. et al. (2009) Molecular biology of the cell 20, 481-97. PMID: 19005208

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human SNX17 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SNX17 Polyclonal Antibody (HC387014)

개요

이미지

참고 문헌

데이터시트

SDS