Anti-Human SPTLC2 Polyclonal Antibody (HT093014)

Name: Anti-Human SPTLC2 Polyclonal Antibody
Brand: abinScience
SKU: HT093014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT093014

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SPTLC2 (Gly186-Gln536).

타겟

LCB2a, SPT 2, Serine palmitoyltransferase 2, LCB 2, KIAA0526, Long chain base biosynthesis protein 2, SPTLC2, LCB2, Long chain base biosynthesis protein 2a, Serine-palmitoyl-CoA transferase 2

정제

Purified by antigen affinity column.

등록번호

O15270

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine palmitoyltransferase 2 (SPTLC2) is a ~62 kDa protein. Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.

1. Han, G. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 8186-91. PMID: 19416851

2. Hornemann, T. et al. (2009) The Journal of biological chemistry 284, 26322-30. PMID: 19648650

3. Gable, K. et al. (2010) The Journal of biological chemistry 285, 22846-52. PMID: 20504773

4. Rotthier, A. et al. (2010) American journal of human genetics 87, 513-22. PMID: 20920666

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human SPTLC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SPTLC2 Polyclonal Antibody (HT093014)

개요

이미지

참고 문헌

데이터시트

SDS

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