

| 카탈로그 번호 | HF576014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human SS18L1 Polyclonal Antibody (HF576014) is a rabbit polyclonal antibody detecting SS18L1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SS18L1 (Thr17-Leu75). | ||||||||
| 타겟 | Calcium-responsive transactivator, CREST, SS18-like protein 1, KIAA0693, SS18L1, SYT homolog 1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O75177 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Calcium-responsive transactivator (SS18L1) is a ~42 kDa protein. Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. | ||||||||
| 참고사항 | For research use only. |
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