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| 카탈로그 번호 | HC385014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human STK3 (Ser15-Asn280). | ||||||||
| 타겟 | STK3, MST2/N, MST-2, STE20-like kinase MST2, Mammalian STE20-like protein kinase 2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, KRS1, MST2, MST2/C | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q13188 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Serine/threonine-protein kinase 3 (STK3) is a ~56 kDa protein. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. 1. Lee, KK. et al. (2001) The Journal of biological chemistry 276, 19276-85. PMID: 11278283 2. Creasy, CL. et al. (1995) Gene 167, 303-6. PMID: 8566796 3. Taylor, LK. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 10099-104. PMID: 8816758 4. Chan, EH. et al. (2005) Oncogene 24, 2076-86. PMID: 15688006 5. Callus, BA. et al. (2006) The FEBS journal 273, 4264-76. PMID: 16930133 6. Ni, L. et al. (2013) Structure (London, England : 1993) 21, 1757-68. PMID: 23972470 7. Kwan, J. et al. (2016) Genes & development 30, 2696-2709. PMID: 28087714 8. Bae, SJ. et al. (2017) eLife 6. PMID: 29063833 9. Tang, Y. et al. (2019) Cell discovery 5, 3. PMID: 30622739 | ||||||||
| 참고사항 | For research use only. |
Lane 1: Mouse brain lysate
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