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| 카탈로그 번호 | HB426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human SULT2A1 Polyclonal Antibody (HB426014) is a rabbit polyclonal antibody detecting Sulfotransferase 2A1; ST2A1; 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3; SULT2A1; HST; STD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human SULT2A1 (Met1-Glu285). | ||||||||
| 타겟 | Sulfotransferase 2A1; ST2A1; 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3; SULT2A1; HST; STD | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q06520 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Sulfotransferase 2A1 (SULT2A1) is a ~33 kDa protein. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids. 1. Chang, HJ. et al. (2004) The Journal of biological chemistry 279, 2689-96. PMID: 14573603 2. Lu, LY. et al. (2008) Molecular pharmacology 73, 660-8. PMID: 18042734 3. Cook, IT. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 2069-78. PMID: 19589875 4. Huang, J. et al. (2010) Xenobiotica; the fate of foreign compounds in biological systems 40, 184-94. PMID: 20102295 5. Gulcan, HO. et al. (2011) Archives of biochemistry and biophysics 507, 232-40. PMID: 21187059 6. Radominska, A. et al. (1990) The Biochemical journal 272, 597-604. PMID: 2268288 7. Abunnaja, MS. et al. (2018) Biochemistry and cell biology = Biochimie et biologie cellulaire 96, 655-662. PMID: 29671343 8. Comer, KA. et al. (1993) The Biochemical journal 289 ( Pt 1), 233-40. PMID: 7678732 9. Glatt, H. et al. (1994) Mutagenesis 9, 553-7. PMID: 7854148 | ||||||||
| 참고사항 | For research use only |
Western blot analysis was performed using anti-SULT2A1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
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