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| 카탈로그 번호 | HP843014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SUV39H2 (Ser192-Cys400). | ||||||||
| 타겟 | Lysine N-methyltransferase 1B, Histone H3-K9 methyltransferase 2, SUV39H2, KMT1B, Su(var)3-9 homolog 2, Histone-lysine N-methyltransferase SUV39H2, H3-K9-HMTase 2, Suppressor of variegation 3-9 homolog 2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9H5I1 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Histone-lysine N-methyltransferase SUV39H2 is a ~46 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. 1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293 2. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126 | ||||||||
| 참고사항 | For research use only. |
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