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| 카탈로그 번호 | HT144014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TAF4 Polyclonal Antibody (HT144014) is a rabbit polyclonal antibody detecting TAF4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TAF4 (Ile834-Ala1010). | ||||||||
| 타겟 | Transcription initiation factor TFIID subunit 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, Transcription initiation factor TFIID 130 kDa subunit, TAF(II)130, TAFII-130, TAFII130, Transcription initiation factor TFIID 135 kDa subunit, TAF(II)135, TAFII-135, TAFII135, TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O00268 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Transcription initiation factor TFIID subunit 4 (TAF4) is a ~110 kDa protein. The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. 1. Chen, X. et al. (2021) Science (New York, N.Y.) 372. PMID: 33795473 2. Gangloff, YG. et al. (2000) Molecular and cellular biology 20, 340-51. PMID: 10594036 3. Tanese, N. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 13611-6. PMID: 8942982 4. Mengus, G. et al. (1997) Genes & development 11, 1381-95. PMID: 9192867 | ||||||||
| 참고사항 | For research use only. |
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