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| 카탈로그 번호 | HX990014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TFAM Polyclonal Antibody (HX990014) is a rabbit polyclonal antibody detecting TFAM in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TFAM (Ser43-Cys246). | ||||||||
| 타겟 | Transcription factor 6-like 2, Mitochondrial transcription factor 1, MtTF1, mtTFA, Transcription factor 6, TCF6, TCF6L2, Transcription factor A, mitochondrial, TCF-6, TFAM | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q00059 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Transcription factor A, mitochondrial (TFAM) is a ~29 kDa protein. Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. 1. Celestini, V. et al. (2018) Cell death & disease 9, 231. PMID: 29445193 2. Hao, Z. et al. (2020) Molecular cell 78, 382-395.e8. PMID: 32183942 3. Hillen, HS. et al. (2017) Cell 171, 1072-1081.e10. PMID: 29149603 4. Litonin, D. et al. (2010) The Journal of biological chemistry 285, 18129-33. PMID: 20410300 5. Rubio-Cosials, A. et al. (2011) Nature structural & molecular biology 18, 1281-9. PMID: 22037172 6. Fisher, RP. et al. (1992) The Journal of biological chemistry 267, 3358-67. PMID: 1737790 7. Gangelhoff, TA. et al. (2009) Nucleic acids research 37, 3153-64. PMID: 19304746 8. Kasashima, K. et al. (2012) Experimental cell research 318, 2335-43. PMID: 22841477 | ||||||||
| 참고사항 | For research use only. |
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