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| 카탈로그 번호 | HB043014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TFE3 (Asn185-Ser281). | ||||||||
| 타겟 | TFE3, bHLHe33, BHLHE33, Transcription factor E3, Class E basic helix-loop-helix protein 33 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P19532 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Transcription factor E3 (TFE3) is a ~61 kDa protein. Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes. 1. Beckmann, H. et al. (1990) Genes & development 4, 167-79. PMID: 2338243 2. Martina, JA. et al. (2014) Science signaling 7, ra9. PMID: 24448649 3. Willett, R. et al. (2017) Nature communications 8, 1580. PMID: 29146937 4. Mathieu, J. et al. (2019) Nature communications 10, 632. PMID: 30733432 5. Lawrence, RE. et al. (2019) Science (New York, N.Y.) 366, 971-977. PMID: 31672913 6. Malik, N. et al. (2023) Science (New York, N.Y.) 380, eabj5559. PMID: 37079666 7. Nardone, C. et al. (2023) Molecular cell 83, 57-73.e9. PMID: 36608670 | ||||||||
| 참고사항 | For research use only. |
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