

| 카탈로그 번호 | HC382014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TLE3 Polyclonal Antibody (HC382014) is a rabbit polyclonal antibody detecting TLE3 in ELISA, IHC, WB. Suitable for Danio rerio, Human, Mouse, Rat, and Xenopus laevis.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TLE3 (Ser449-Tyr772). | ||||||||
| 타겟 | Transducin-like enhancer protein 3, KIAA1547, TLE3, Enhancer of split groucho-like protein 3, ESG3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q04726 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Transducin-like enhancer protein 3 (TLE3) is a ~83 kDa protein. Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes. 1. Flack, JE. et al. (2017) Molecular cell 67, 181-193.e5. PMID: 28689657 | ||||||||
| 참고사항 | For research use only. |
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