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| 카탈로그 번호 | HP219014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TMEM165 Polyclonal Antibody (HP219014) is a rabbit polyclonal antibody detecting TMEM165 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TMEM165 (Gly34-Thr89). | ||||||||
| 타겟 | TPARL, TMEM165, Transmembrane protein PT27, Transmembrane protein TPARL, Transmembrane protein 165 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9HC07 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Putative divalent cation/proton antiporter TMEM165 is a ~34 kDa protein. Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk. The transport mechanism and stoichiometry remains to be elucidated. 1. Foulquier, F. et al. (2012) American journal of human genetics 91, 15-26. PMID: 22683087 2. Demaegd, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 6859-64. PMID: 23569283 3. Potelle, S. et al. (2016) Human molecular genetics 25, 1489-500. PMID: 27008884 4. Stribny, J. et al. (2020) The Journal of biological chemistry 295, 3865-3874. PMID: 32047108 | ||||||||
| 참고사항 | For research use only. |
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