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| 카탈로그 번호 | HS768014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TMEM97 (Gln31-Ser68). | ||||||||
| 타겟 | Sigma-2 receptor, Sigma intracellular receptor 2, Meningioma-associated protein 30, MAC30, Transmembrane protein 97, S2R, TMEM97, Sigma2 receptor | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q5BJF2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Sigma intracellular receptor 2 (TMEM97) is a ~20 kDa protein. Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface (Probable). Forms a ternary complex with PGRMC1 receptor and low density lipoprotein receptor/LDLR at the plasma membrane, which increases LDLR-mediated LDL cholesterol internalization. Decreases lysosomal sterol transporter NPC1 availability to the cell, probably through NPC1-binding, hence controlling lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome. Binds regio- and stereoselective ligand 20(S)-hydroxycholesterol (20(S)-OHC) which enhances TMEM97-NPC1 interaction and decreases TMEM97-PGRMC1 and TMEM97-TSPO interactions, thereby linking OHC binding to cholesterol homeostasis. Also able to bind cholesterol. 1. Bartz, F. et al. (2009) Cell metabolism 10, 63-75. PMID: 19583955 2. Huang, YS. et al. (2014) Medicinal research reviews 34, 532-66. PMID: 23922215 3. Guo, L. et al. (2015) Current medicinal chemistry 22, 989-1003. PMID: 25620095 4. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690 5. Alon, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 7160-7165. PMID: 28559337 6. Riad, A. et al. (2018) Scientific reports 8, 16845. PMID: 30443021 7. Son, KN. et al. (2021) The FEBS journal 288, 6815-6827. PMID: 34233061 8. Cheng, YS. et al. (2021) Nature chemical biology 17, 1271-1280. PMID: 34799735 9. Ma, D. et al. (2022) International journal of oral science 14, 42. PMID: 35970844 | ||||||||
| 참고사항 | For research use only. |
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