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| 카탈로그 번호 | HF637014 | ||||||||
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| 설명 |
Anti-Human TOX Polyclonal Antibody (HF637014) is a rabbit polyclonal antibody detecting TOX in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TOX (Val265-Val341). | ||||||||
| 타겟 | Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX, TOX, KIAA0808 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O94900 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Thymocyte selection-associated high mobility group box protein TOX is a ~57 kDa protein. Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis. Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2. 1. Yun, S. et al. (2011) Immunology letters 136, 29-36. PMID: 21126536 | ||||||||
| 참고사항 | For research use only. |
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