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| 카탈로그 번호 | HC342013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | SAA0236 | ||||
| 타겟 | TP53-binding protein 1, TP53BP1, p53-binding protein 1, p53BP1, 53BP1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q12888 | ||||
| RRID | Anti-Human TP53BP1 IP Antibody (SAA0236) (abinScience Cat# HC342013, RRID:AB_3729770) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | TP53-binding protein 1 (TP53BP1) is a ~213 kDa protein. Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. 1. Wang, B. et al. (2002) Science (New York, N.Y.) 298, 1435-8. PMID: 12364621 2. Botuyan, MV. et al. (2006) Cell 127, 1361-73. PMID: 17190600 3. Kang, Y. et al. (2011) Biochemical and biophysical research communications 404, 476-81. PMID: 21144835 4. Chapman, JR. et al. (2012) Journal of cell science 125, 3529-34. PMID: 22553214 5. Escribano-Díaz, C. et al. (2013) Molecular cell 49, 872-83. PMID: 23333306 6. Jacquet, K. et al. (2016) Molecular cell 62, 409-421. PMID: 27153538 7. Drané, P. et al. (2017) Nature 543, 211-216. PMID: 28241136 8. Bigot, N. et al. (2019) eLife 8. PMID: 31135337 9. Swift, ML. et al. (2023) Nature structural & molecular biology 30, 1456-1467. PMID: 37696958 | ||||
| 참고사항 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human TP53BP1 IP Antibody (SAA0236)
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