Anti-Human TREX1 Polyclonal Antibody (HV590024)

Name: Anti-Human TREX1 Polyclonal Antibody
Brand: abinScience
SKU: HV590024
Price: 168 USD
Availability: InStock

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50ug
100ug

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HV590024

설명

Anti-Human TREX1 Polyclonal Antibody (HV590024) is a rabbit polyclonal antibody detecting TREX1. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TREX1 (Met11-His222).

타겟

3'-5' exonuclease TREX1, DNase III, Deoxyribonuclease III, EC:3.1.11.2, TREX1, Three-prime repair exonuclease 1

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q9NSU2

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904

2. Höss, M. et al. (1999) The EMBO journal 18, 3868-75. PMID: 10393201

3. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595

4. Mohr, L. et al. (2021) Molecular cell 81, 724-738.e9. PMID: 33476576

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human TREX1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TREX1 Polyclonal Antibody (HV590024)

개요

이미지

참고 문헌

데이터시트

SDS