中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HF807014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TRIM13 Polyclonal Antibody (HF807014) is a rabbit polyclonal antibody detecting TRIM13 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TRIM13 (Met1-Arg153). | ||||||||
| 타겟 | E3 ubiquitin-protein ligase TRIM13, 2.3.2.27, B-cell chronic lymphocytic leukemia tumor suppressor Leu5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RING finger protein 77, RING-type E3 ubiquitin transferase TRIM13, Ret finger protein 2, Tripartite motif-containing protein 13, TRIM13, LEU5, RFP2, RNF77 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O60858 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | E3 ubiquitin-protein ligase TRIM13 is a ~46 kDa protein. Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. 1. Tomar, D. et al. (2012) Biochimica et biophysica acta 1823, 316-26. PMID: 22178386 2. Huang, B. et al. (2017) Molecular pharmacology 91, 307-316. PMID: 28087809 3. Hatchi, EM. et al. (2014) The international journal of biochemistry & cell biology 54, 217-22. PMID: 25088585 4. Tomar, D. et al. (2014) Cellular signalling 26, 2606-13. PMID: 25152375 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-TRIM13 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
